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Switching Strategies to Mitigate HIV Mutation

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3 Author(s)
Hernandez-Vargas, E.A. ; Dept. of Syst. Immunology, Helmholtz Centre for Infection Res., Braunschweig, Germany ; Colaneri, P. ; Middleton, R.H.

HIV mutates rapidly and may develop resistance to specific drug therapies. There is no general agreement on how to optimally schedule the available treatments for mitigating the effects of mutations. With a switched positive linear system, we examined different control strategies applied to a higher order nonlinear mutation model. Simulation results suggest that model predictive control could outperform the common clinical treatment recommendations. This brief is a step forward to develop further tools for helping the practitioners to find the optimal treatment schedule.

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Control Systems Technology, IEEE Transactions on  (Volume:22 ,  Issue: 4 )