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In this study, the authors present a cooperative spectrum sensing scheme based on opportunistic amplify-and-forward relaying (denoted by CSS-OAFR), which provides higher detection performance by selecting the best cognitive relay and is interesting in distributed cognitive radio networks. Moreover, the authors focus on the detection performance using the energy detector over independent and non-identically distributed Nakagami-m fading channels. In particular, a tight closed-form lower bound of the average missed-detection probability is derived for the convenience of performance evaluation in practice. Finally, simulations are provided to validate the CSS-OAFR scheme and the derived closed-form lower bound.