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The ESA research project “Application of KLIMA Algorithm to CO2 Retrieval from IASI/METOP-A Observations and Comparison with TANSO-FTS/GOSAT Products” aims to develop a dedicated software, based on the KLIMA inversion algorithm (originally proposed by IFAC-CNR for the 6 ° cycle of ESA Earth Explorer Core Missions), suited for CO2 retrieval and integrated into the ESA grid-based operational environment Grid Processing On-Demand (G-POD) to process Level 1 data acquired by the infrared atmospheric sounding interferometer (IASI) and to perform a comparison with Thermal And Near-infrared Sensor for carbon Observation Fourier Transform Spectrometer (TANSO-FTS), on board of the Greenhouse gases Observing SATellite (GOSAT), Level 2 data. In order to obtain a reasonable capacity to bulk processing IASI data, we choose to integrate the KLIMA code into the G-POD system. For this reason, we investigated an optimized version of the KLIMA algorithm, aiming at developing a nonoperational retrieval code with adequate features for the integration on the G-POD system. The optimized version of KLIMA retrieval code has been completed and integrated on the G-POD operational environment and is available for bulk processing of IASI data. Using the KLIMA inversion code integrated into the ESA G-POD, it was possible to perform an extensive comparison of a selected set of IASI measurements collocated with TANSO-FTS observations. We performed an extensive comparison of the column-average CO2 dry air mole fraction (XCO2) retrieved from IASI measurements by using the KLIMA/G-POD inversion code with the operational Level 2 SWIR products (Version 01.xx and Version 02.xx) from collocated TANSO-FTS observations. In this work, we describe the strategy adopted for the comparison and we show the results of this activity.