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This paper reports on the design optimization done for Double Sided silicon microStrip Detectors (DSSDs) to reduce the Equivalent Noise Charge (ENC) and to maximize the breakdown voltage and Charge Collection Efficiency. Various isolation techniques have been explored and a detailed comparison has been studied to optimize the detector performance. To evaluate the performance of the silicon detectors, a radiation damage model has been included. The neutron fluence is expected to be 2 × 1013 neqcm-2 per year for five years of expected CBM run with intermediate periods of warm maintenance, cold maintenance and shutdown. Transient simulations have been performed to estimate the charge collection performance of the irradiated detectors and simulations have been verified with experimental data.