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Femtocells have emerged as a promising solution to provide wireless broadband access coverage in cellular dead zones and indoor environments. Compared with other techniques for indoor coverage, femtocells achieve better user experience with less capital expenditure and maintenance cost. However, co-channel deployments of closed subscriber group femtocells cause coverage holes in macrocells due to co-channel interference. To address this problem, cognitive radio technology has been integrated with femtocells. CR-enabled femtocells can actively sense their environment and exploit the network side information obtained from sensing to adaptively mitigate interference. We investigate three CR-enabled interference mitigation techniques, including opportunistic interference avoidance, interference cancellation, and interference alignment. Macrocell activities can be obtained without significant overhead in femtocells. In this article, we present a joint opportunistic interference avoidance scheme with Gale-Shapley spectrum sharing (GSOIA) based on the interweave paradigm to mitigate both tier interferences in macro/femto heterogeneous networks. In this scheme, cognitive femtocells opportunistically communicate over available spectrum with minimal interference to macrocells; different femtocells are assigned orthogonal spectrum resources with a one-to-one matching policy to avoid intratier interference. Our simulations show considerable performance improvement of the GSOIA scheme and validate the potential benefits of CR-enabled femtocells for in-home coverage.