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Climate change can have an impact on natural and human systems. This is usually the case with renewable-energy-based energy systems, given their close dependence on climate conditions. For instance, long-term changes in temperature, precipitation, and wind shear, among other factors, can affect the operation of existing energy systems and even compromise the viability of new entrepreneurships. Therefore, global climate change can add a significant amount of uncertainty to the already uncertain operation of renewable energy systems. This article gives an overview of the issues related to climate change impacts on hydropower production with a focus on Amazonian regions.