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Deep brain stimulation is an important therapy for Parkinson's disease patients. However, the current deep brain stimulator is open loop and cannot automatically adapt the stimulation according to the patient's condition. In this reported study a real-time wake/sleep identification device has been developed to wirelessly control the stimulation according to the patient's wake/sleep states. The wake/sleep identification was based on the wrist movement, and the identified result was transmitted wirelessly to the implantable pulse generator. This device showed a reliable radio frequency communication within 2 m and a low level of current consumption. This device also showed a good performance of real-time wake/sleep identification on Parkinson's disease patients. This study provides a promising application in the closed-loop deep brain stimulation, as well as other applications in medical services, such as night care, and fall alarm.