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To improve reliability of packet transmission, wireless communication systems use appropriate retransmission schemes based on characteristics of each protocol layer. In each protocol layer, retransmission schemes operate without cooperation of other layers. However, to improve system performance over wireless channel, a retransmission scheme of each protocol layer can use information on other protocol layers. For this reason, the cross-layer retransmission schemes recently have been proposed. The cross-layer retransmission scheme that is an retransmission scheme combined with adaptive modulation and coding (AMC) scheme can improve average spectral efficiency by considering both wireless channel state and parameters of a retransmission scheme. However, conventional researches concentrate on improving system performance over wireless channel and the end-to-end performance is not considered. It may be difficult to find an appropriate cross-layer retransmission scheme and system parameters for each service class. Thus, the end-to-end performance should be analyzed to decide whether the cross-layer retransmission schemes and parameters are suitable for each service class. In this paper, we analyze the end-to-end performance of wireless communication system using a cross-layer retransmission scheme and evaluate the system performance such as spectral efficiency, packet error rate (PER), and end-to-end throughput on transport layer. From the evaluation results, it can be seen that the end-to-end throughput of the hybrid automatic repeat request (HARQ) scheme combined with AMC is superior to that of automatic repeat request (ARQ) combined with AMC.