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Important discoveries are being made using computational modeling. Modeling is used in designing new therapeutics, and new biocomputational tools are being developed. One measure of this quickly advancing field is the growing number of computational-biology publications in major biological and general science journals as well as the creation of new journals devoted to computational modeling. At universities, too, students are flocking to computational biology programs.From the expert's view, computational systems biology, including multiscale modeling, will be at the forefront of the transformation of medicine.