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In this spotlight, advances in four topics in biomedical imaging are described. This does not begin to cover all of the advances in the field, but include topics that remain the most compelling in terms of mortality (cardiovascular disease) and increasing concern (Chronic Obstructive Pulmonary Disease, (COPD)). We also report on some very exciting progress in making methods of MR spectroscopy more reliable and robust, thus suitable for wider clinical use. Finally, we describe recent developments in nuclear and molecular imaging related to diagnosis and treatment of cancer.