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In mixed radio-frequency (RF) and digital designs, noise from high-speed digital circuits can interfere with RF receivers, resulting in RF interference issues such as receiver desensitization. In this paper, an effective methodology is proposed to estimate the RF interference received by an antenna due to near-field coupling, which is one of the common noise-coupling mechanisms, using decomposition method based on reciprocity. In other words, the noise-coupling problem is divided into two steps. In the first step, the coupling from the noise source to a Huygens surface that encloses the antenna is studied, with the actual antenna structure removed, and the induced tangential electromagnetic fields due to the noise source on this surface are obtained. In the second step, the antenna itself with the same Huygens surface is studied. The antenna is treated as a transmitting one and the induced tangential electromagnetic fields on the surface are obtained. Then, the reciprocity theory is used and the noise power coupled to the antenna port in the original problem is estimated based on the results obtained in the two steps. The proposed methodology is validated through comparisons with full-wave simulations. It fits well with engineering practice, and is particularly suitable for prelayout wireless system design and planning.