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Computer-based decision support (CDSS) systems can deliver real patient care and increase chances of long-term survival in areas of chronic disease management prone to poor control. Computer-based Decision Support Systems (CDSS) can provide candidate opinions based on available data that clinicians can use (or not) to shape their strategy for managing the condition. One such CDSS, for the management of warfarin for anticoagulation, is described in this paper and the outcomes shown. Data is derived from the system implemented and running and show a performance consistently around 20% better than the applicable guidelines.