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During the pharmaceutical production process, the quality detection is a very important part. Intelligent detection based on machine vision technology is a rapid and automatic means of drug production quality detection and control of drug production. A method is proposed for the packaging detection of pharmaceutical glass bottle which is based on machine vision technology. It is suitable for real-time detection and control. That is, through the computer vision system, collecting glass bottles image and using the mechanical vision software for detection, and the final decision to make judgments can be concluded. Based on the machine vision software HALCON, this article describes the software platforms and structural levels of pharmaceutical bottle packaging line detection systems, as well as the detection and control process. It is pointed out that the detection system features and application prospects.