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Commercially available computer-controlled SQUID electronics are usually delivered with software providing a basic user interface for adjustment of superconducting quantum interference device (SQUID) tuning parameters, such as bias current, flux offset, and feedback loop settings. However, in a research context it would often be useful to be able to modify this code and/or to have full control over all these parameters from researcher-written software. In the case of the STAR Cryoelectronics PCI/PFL family of SQUID control electronics, the supplied software contains modules for automatic tuning and noise characterization, but does not provide an interface for user code. On the other hand, the Magnicon SQUIDViewer software package includes a public application programming interface, but lacks auto-tuning and noise characterization features. To overcome these and other limitations, we are developing an “open-source” framework for controlling SQUID electronics, which should provide maximal interoperability with user software, a unified user interface for electronics from different manufacturers, and a flexible platform for the rapid development of customized SQUID auto-tuning and other advanced features. We have completed a first implementation for the STAR Cryoelectronics hardware and have made the source code for this ongoing project available to the research community on SourceForge (http://opensquid.sourceforge.net) under the GNU public license.