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New architecture for patterning gene expression using zinc finger proteins and small RNAs

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4 Author(s)
Hsia, J. ; Dept. of Electr. Eng. & Comput. Sci., Univ. of California, Berkeley, Berkeley, CA, USA ; Holtz, W.J. ; Maharbiz, M.M. ; Arcak, M.

In our search for a viable synthetic gene network that can spontaneously produce patterning, we previously identified a new class of networks that we call quenched oscillator systems. These systems consist of a primary feedback loop that serves as an oscillator and a secondary feedback loop that quenches the oscillations and incorporates a diffusible molecule. We demonstrated that quenched oscillator systems are capable of generating spatio-temporal patterning with appropriate parameter values. Here we take advantage of recent work with zinc finger proteins (ZFPs) and small RNAs (sRNAs) to propose a new implementation using a new oscillator subsystem and a modified quenching loop.

Published in:

Decision and Control (CDC), 2012 IEEE 51st Annual Conference on

Date of Conference:

10-13 Dec. 2012