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We modify our latest reported methodology for implantable antenna design in an attempt to further accelerate the design while achieving optimized resonance characteristics. Design is performed inside a small-sized single- or multilayer tissue box for the single-layer tissue model (SLTM) and the multilayer tissue model (MLTM) variations, respectively. Given a specific medical application scenario, the idea is to take into account the dielectric loading of the surrounding tissues and exterior air on the antenna while using an adequately small tissue model to speed up simulations. Effectiveness of the methodology is assessed for antenna design aimed at intracranial pressure (ICP) monitoring and cardiac pacemaker applications. The MLTM variation provides more accurate results than the SLTM at the expense of being slightly more complex and slow.