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Wireless communication systems at high data rates and low power consumptions are currently in high demand. Power efficiency becomes a critical issue for technology that will be used in 3G and 4G technologies. Orthogonal frequency-division multiplexing (OFDM) is a technique using discrete multi-tone modulation with each subcarrier modulating in a conventional modulation scheme. On the other hand, Multiple- Input Multiple-Output (MIMO) systems have become the attention of wireless academic community and industry because of their promising ability to increase capacity and performance with acceptable Bit Error Rate (BER) proportionally with the increased number of antennas. In this paper, MIMO-OFDM system using Vertical Bell Lab lAyered Space Time (V-BLAST) is developed by considering Minimum Mean Square Error (MMSE) and Zero Forcing (ZF) detector mechanisms for various modulation schemes and antenna configurations. The performance parameter of MIMO-OFDM in terms of BER is determined and analysed for two different detector schemes such as MMSE and ZF with the help of MATLAB package.