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In this paper, we investigate a dynamic spectrum sharing problem for the centralized uplink cognitive radio networks using orthogonal frequency division multiple access. We formulate a large-scale joint rate and power allocation as an optimization problem under quality of service constraint for secondary users and interference constraint for primary users. We also suggest admission control to find a feasible solution to the optimization problem. To implement the resource allocation on a large-scale, we introduce a notion of using the conservative factors α and β depending on the outage and violation probabilities. Since estimating instantaneous channel gains is costly and requires high complexity, the proposed algorithm pursues a practical and implementation-friendly resource allocation. Simulation results demonstrate that the large-scale joint rate and power allocation incurs a slight loss in system throughput over the instantaneous one, but it achieves lower complexity with less sensitivity to variations in shadowing statistics.