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Motif finding is an important part of bioinformatics studies. This paper proposed an algorithm used for automatic motif finding. Gaussian Mixture Model is applied to build a motifs finding model in promoter sequence. The fuzzy cluster is used to determine the optimal numbers of GMM components and apply the initial values for the expectation maximization (EM) algorithm which is used to obtain the parameter estimates. The approach can identify the most important motifs around transcription start site and can also be used for other biological functional sequences motif finding. The simulation results show the proposed method is more effective for different motif finding than finding tools proposed in paper  and improves the precision of detection.
Control Conference (CCC), 2012 31st Chinese
Date of Conference: 25-27 July 2012