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Aiming at difficult problems of Inconsistent of probability and logic expressions and high-end probability logical reasoning for solving domain knowledge. This paper proposes a domain knowledge uncertainty reasoning method with a combination of Bayesian network and conditional event algebra. This method used Bayesian formula combining with the conditional independence assumption to do causal reasoning existing in a variety of graphs according to the high efficiency of expressing uncertainty reasoning by Bayesian network, and transformed a higher-order conditional event to normal event solution via Condition Event Algebra, so the uncertainty reasoning solution of domain knowledge can be realized. Through analyzing an uncertain reasoning case solving based on the tourism domain ontology, the results show that the proposed method is effective, and can well solve approximate reasoning problems of domain knowledge uncertainty reasoning.