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In a SOA-based system the applications are organized in a manner such that interoperable services can be used from different domains. In a process industry context, different domains can refer to, for example, process instrumentation and monitoring, execution of process control, data acquisition, etc. Large process industry systems are a complex and potentially very large sets of multi-disciplinary, heterogeneous, networked distributed systems. Current industrial process control systems are typically vendor specific; in addition the different domains are associated with different layers, different standards and different technologies. In the paper the authors report about the investigations and assessments performed to find answers for four major critical questions that arise as key when technologies have to be selected and used in a true Service Oriented Architecture (SOA) based distributed large scale Process Monitoring and Control system: (1) Real-time SOA (what are the limits of bringing SOA into high performance control loops?); (2) Management of large scale industrial distributed control systems (is it feasible to manage up to tens of thousands of service-oriented devices?); (3) Distributed event-based systems are asynchronous (what are the limits compared to traditional periodic scanning systems?) and (4) Service specification (which semantics are the most suitable for specifying process control and monitoring services?).