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Currently, the MRI brain image processing is a vast area of research, several methods and approaches have been used to segment these images (thresholding, region, contour, clustering). In this work, we propose a novel segmentation approach, which is based on fuzzy c-means clustering and using possibilist c-means approach. To validate our approach, we have tested successfully on several datasets of real images MRI. Thus, to show the performance of our method, we compared our results with different segmentation algorithms: k-means, fuzzy c-means, and possibilist c-means.