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Applications of advanced electronic technologies have greatly increased the efficiency and performance of safety-critical computer systems. In addition, the architectural flexibility of these systems reduces the types of printed circuit boards they can use, thereby reducing difficulties with maintenance. A newly developed safety-critical computer system is presented in this paper. The system uses some advanced electronic technologies and can be reconfigured to be a triple-modular-redundant system or a dual-modular-duplex-redundant system for different applications. The system's architecture and fail-safe technologies are discussed, and its reliability, availability, maintainability, and safety (RAMS) are evaluated based on the Markov method. Based on these evaluations, the safety-critical computer system developed herein demonstrates great potential for rail use.