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Traditional Chinese medicine (TCM) is developed from clinical practice. Rich information can be obtained from the medical record of TCM. National clinical research data center of TCM is constructed to collect the clinical medical data of TCM from hospitals all over the country. The construction framework of national clinical data center of TCM includes infrastructure construction, software construction, local branch data center construction and institutional framework. In the mean time, a series of measures is implemented to guarantee the normal running of the national clinical data center of TCM. The construction of national clinical data center of TCM may promote the development of TCM and improve the level of medical care in China.