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Full life cycle health records service is the core of the regional health information platform. The file information which is various and massive includes basic personal information, major diseases and health problems, women and children health information, disease prevention and control, disease management information. Because of different targets, we need different ways to show and have an efficient way to carry out of the business system, these data also can be assembled for the people-centered health information. Based on these requirements, we propose an data center architecture which separating business from data storage in exchanging. It links the workflow with all kinds of service on one hand and. On the another hand, it is able to accommodate the expansion of personal health information database. Compare the architecture with the traditional three-level, the paper highlights the performance of its advantages and points out the trend on future.