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Effects of water molecules on binding kinetics of peptide receptor on a piezoelectric microcantilever

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7 Author(s)
Hui Kim, Sang ; Department of Electrical Engineering, Kwangwoon University, 447-1, Wolgye, Nowon, Seoul 139-701, Korea ; Kyoung Yoo, Yong ; Chae, Myung-Sic ; Yoon Kang, Ji
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The use of highly selective reversible peptide receptors is essential for cantilever-based electronic nose systems. Here, we present the effects of water molecules on the binding kinetics of 2,4-dinitrotoluene (DNT) molecules with DNT selective peptide receptors linked with a tri(ethylene glycol)-based (TEG) self-assembled monolayer (SAM) in a gas phase in a piezoelectric microcantilever sensor. We observed 1.5-times faster reaction kinetics in wet conditions compared with dry conditions. In a dissociation step, distinctive differences in the recovery time were observed in wet conditions, which could be attributed to water retention efficiency of TEG-linkers for the conformation of biomolecules.

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Applied Physics Letters  (Volume:101 ,  Issue: 23 )