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Fluorescence resonance energy transfer-based molecular logic circuit using a DNA scaffold

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3 Author(s)
Nishimura, Takahiro ; Graduate School of Information Science and Technology, Osaka University, Osaka 565-0871, Japan ; Ogura, Yusuke ; Tanida, Jun

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This paper presents a method of information processing using biomolecular input signals and fluorescence resonance energy transfer (FRET) signaling constructed on a DNA scaffold. Logic operations are achieved by encoding molecular inputs into an arrangement of fluorescence dyes using simple DNA reactions and by evaluating a logic expression using local photonic signaling that is much faster than DNA reactions. Experimental results verify the operation of a complete set of Boolean logic functions (AND, OR, NOT) and combinational logic operations using a FRET-signal cascade.

Published in:

Applied Physics Letters  (Volume:101 ,  Issue: 23 )

Date of Publication:

Dec 2012

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