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A fiber-bundle microprobe coupled to a confocal optical microscope is shown to enable multicolor in vivo fluorescence brain imaging. A bundle of several thousands of 2.4-μm-diameter optical fibers is employed to deliver multiwavelength laser excitation radiation and to transmit multicolor images from hippocampus tissues in living transgenic mice by picking up a multiplex fluorescent response from green fluorescent protein, nucleic acid counterstains, and neuron tracers.
Published in:
Applied Physics Letters
(Volume:101
,
Issue:
23
)
Date of Publication: Dec 2012
- Page(s):
- 233702 - 233702-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.4767386
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 06 December 2012
- Issue Date :
- Dec 2012
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