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This paper analyzes the underlay and overlay mode selection of Device-to-Device (D2D) communication in the LTE-Advanced single-cell scenario. The two cases that the cell contains relay node or not are considered, and the study focuses on the location relationship between cellular UE and D2D UE. Our evaluation shows that whether D2D communication can reuse the cellular uplink resource or not is affected by the system parameters. Specifically the underlay mode is preferred when the cellular user is closer to the BS or relay node than the D2D user. The simulations show that the introduction of relay node enables D2D pairs to have more chances to share the resources with cellular user in the underlay mode.