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We develop cognitive resource allocation scheme to mitigate co-tier and cross-tier interference in overlay femtocell networks. By exploiting statistical models for characterizing multitier interference, our scheme avoids prohibitive exchange of realtime interference statistics in the network. The proposed scheme is independently implemented at each femtocell and allocates resources distributedly in response to the probabilistic interference conditions in the network. This “self-organizing” framework can be useful to address interference management in dense, ad-hoc, and consumer-deployed femtocell networks. Simulation results show that the proposed scheme can improve the throughput of femtocell links while simultaneously reducing cross-tier interference.