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In this paper, a novel low complexity bit and power loading algorithm is formulated for orthogonal frequency division multiplexing (OFDM) systems operating in fading environments and in the presence of unknown interference. The proposed non-iterative algorithm jointly maximizes the throughput and minimizes the transmitted power, while guaranteeing a target bit error rate (BER) per subcarrier. Closed-form expressions are derived for the optimal bit and power distributions per subcarrier. The performance of the proposed algorithm is investigated through extensive simulations. A performance comparison with the algorithm shows the superiority of the proposed algorithm with reduced computational effort.