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Digital Signal Processing (DSP) is a modern digital technique for processing signals. Such digital manipulation technique is computationally intensive. Hence, DSPs are traditionally deployed on modern desktop computers, or on specialized processors called digital signal processors (DSPs). Development and verification of real-time DSP algorithm, on low-power battery-operated device, is a challenging task. The absence of an available real-time operating system on these devices further delays the development and design verification process. In this paper, a methodology to implement health monitoring DSP algorithms onto wireless sensor node (WSN) hardware is proposed. Firstly, a DSP pre-processing technique was investigated and identified for benchmarking. Secondly, a suitable DSP hardware platform for DSP deployment was investigated. Thirdly, a Real-Time (RT) Hardware-in-the-Loop (HIL) simulator system was developed to verify the DSP algorithm implementation. It is shown that the proposed methodology and RT HIL simulator system compliment each other; The RT HIL simulator system is the next best thing to a real testbed.