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Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations

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2 Author(s)
Woods, S.P. ; Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK ; Constandinou, T.G.

This paper describes a platform to achieve targeted drug delivery in the next-generation wireless capsule endoscopy. The platform consists of two highly novel subsystems: one is a micropositioning mechanism which can deliver 1 ml of targeted medication and the other is a holding mechanism, which gives the functionality of resisting peristalsis. The micropositioning mechanism allows a needle to be positioned within a 22.5° segment of a cylindrical capsule and be extendible by up to 1.5 mm outside the capsule body. The mechanism achieves both these functions using only a single micromotor and occupying a total volume of just 200 mm3. The holding mechanism can be deployed diametrically opposite the needle in 1.8 s and occupies a volume of just 270 mm3. An in-depth analysis of the mechanics is presented and an overview of the requirements necessary to realize a total system integration is discussed. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule microrobots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:60 ,  Issue: 4 )