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Detection of baroreceptor activity in rat vagal nerve recording using a multi-channel cuff-electrode and real-time coherent averaging

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6 Author(s)
Dennis T. T. Plachta ; Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, University of Freiburg, Germany ; Nayeli Espinosa ; Mortimer Gierthmuehlen ; Oscar Cota
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Electrical stimulation of afferent nerve fibers originating from pressure sensors can trigger the baroreflex to reduce blood pressure and might be an alternative to treat patients with hypertension. In this study, baroreceptor compound activity was detected using multi-channel cuff-electrode recordings on rat vagal nerve. In order to isolate the vagal nerve signals from external potentials (such as ECG- and EMG-coupling), a tripolar measuring technique was applied. To eliminate noise and neural signals corresponding to other organs, coherent averaging was used. The baroreceptor-correlated signals appear predominantly in one of the electrode channels, presumably close to the corresponding neural substrate. This localization was done in real-time.

Published in:

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Date of Conference:

Aug. 28 2012-Sept. 1 2012