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This article presents an ultra-compact green Bio-regulator dedicated for brain cortical implant using a dynamic PSR enhancement technique. This novel technique enabled the regulator to achieve a very high power supply rejection (PSR) of -58dB and -78dB at 1 MHz and 10MHz respectively. The Bioregulator achieves a very low quiescent current of 2μA coupled with an ultra-low power consumption of 1.8μW. This Bioregulator, simulated with Global Foundries 0.18μm CMOS process, yields a stable output voltage of 0.5V with a supply voltage ranging from 0.9-1.2V. Its distinct features, ultra-low power consumption and high PSRR at 1MHz and 10MHz, make it ideally suitable for biomedical brain cortical implant.