Quantitative ultrasound visualization of cell death: Emerging clinical applications for detection of cancer treatment response

Differentiable echogeneities exhibited by living and dead cells enables the monitoring of cell death response via quantitative ultrasound techniques at high-frequencies and recently at clinical range frequencies. Such capability can be potentially employed to provide rapid and quantitative functional information in real time, and at the patient bedside for evaluating therapy response early following treatment. This paper summarizes backgrounds on quantitative ultrasound visualization of cell death and highlights its potential capabilities for monitoring cancer treatment response, where favorable results have been reported, according to a recent pilot clinical study.