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A nonlocal kernel regression (NL-KR) model is presented in this paper for various image and video restoration tasks. The proposed method exploits both the nonlocal self-similarity and local structural regularity properties in natural images. The nonlocal self-similarity is based on the observation that image patches tend to repeat themselves in natural images and videos, and the local structural regularity observes that image patches have regular structures where accurate estimation of pixel values via regression is possible. By unifying both properties explicitly, the proposed NL-KR framework is more robust in image estimation, and the algorithm is applicable to various image and video restoration tasks. In this paper, we apply the proposed model to image and video denoising, deblurring, and superresolution reconstruction. Extensive experimental results on both single images and realistic video sequences demonstrate that the proposed framework performs favorably with previous works both qualitatively and quantitatively.