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Detection of Cancer Using Advanced Computerized Analysis of Infrared Spectra of Peripheral Blood

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7 Author(s)
Ostrovsky, E. ; Dept. of Biomed. Eng., Ben-Gurion Univ. of the Negev, Beer-Sheva, Israel ; Zelig, U. ; Gusakova, I. ; Ariad, S.
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We have developed a novel approach for detection of cancer based on biochemical analysis of peripheral blood plasma using Fourier transform infrared spectroscopy. This approach has proven to be quick, safe, minimal invasive, and effective. Our approach recognizes any signs of solid tumor presence, regardless of location in the body or cancer type by measuring a spectrum that gives information regarding the total molecular composition and structure of the peripheral blood samples. The analysis includes clinically relevant preprocessing and feature extraction with principal component analysis, and uses Fisher's linear discriminant analysis to classify between cancer patients and healthy controls. We evaluated our method with leave-one-out cross validation and were able to establish sensitivity of 93.33%, specificity of 87.8%, and overall accuracy of 90.7%. Using our method for cancer detection should result in fewer unnecessary invasive procedures and yield fast detection of solid tumors.

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Biomedical Engineering, IEEE Transactions on  (Volume:60 ,  Issue: 2 )