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Monokine induced by interferon gamma (MIG) is an important biomarker for early monitoring of transplant rejection. This letter presents a novel technique for detecting human MIG by using immunologically-modified field effect transistors. Detection of MIG with anti-MIG antibody in high concentration phosphate buffer saline solution was achieved for the first time. To provide specific MIG detection capability, anti-MIG IgG molecular affinity interface receptors were formed on a short self-assembled monolayer on a floating gold sensing gate of a biochemically modified AlGaN/GaN high electron mobility transistor device.