Referenced Items are not available for this document.
One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.
Published in:
System Science, Engineering Design and Manufacturing Informatization (ICSEM), 2012 3rd International Conference on
(Volume:1
)
Date of Conference: 20-21 Oct. 2012
- Page(s):
- 51 - 54
- Print ISBN:
- 978-1-4673-0914-1
- INSPEC Accession Number:
- 13116169
- Conference Location :
- Chengdu
- Digital Object Identifier :
- 10.1109/ICSSEM.2012.6340764
- Product Type:
- Conference Publications
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