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The topological features of nonessential-nonhub proteins in the protein-protein interaction network

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4 Author(s)
Dong Yun-yuan ; Coll. of Comput., Nat. Univ. of Defense Technol., Changsha, China ; Yang Jun ; Liu Qi-jun ; Wang Zheng-hua

One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.

Published in:

System Science, Engineering Design and Manufacturing Informatization (ICSEM), 2012 3rd International Conference on  (Volume:1 )

Date of Conference:

20-21 Oct. 2012