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Calcium signaling: overview and research directions of a molecular communication paradigm

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3 Author(s)
Kuran, M.S. ; ISTANBUL UNIVERSITY ; Tugcu, T. ; Edis, B.O.

In the ongoing effort to build micro- and nanoscale machines, one of the key approaches is the bio-hybrid approach, which focuses on the use of biological constructs and engineered cells. As a natural extension of this concept to nanoscale communication, molecular communication is an umbrella term encompassing various communication systems that are built based on biological intra- and intercellular communication methods, most of which use molecules and molecular concentration as the information carrier. Compared to other proposed molecular communication systems such as diffusion-based communication and microtubular networks, calcium signaling is expected to provide a faster and more controllable system that is suitable for information dissemination and group behavior in nanoscale sensor networks. In this article, we give a general overview of calcium signaling, a novel communication paradigm that uses intercellular calcium waves in biology as a baseline, explain its capabilities, limitations, and some possible deployment scenarios. We also describe various open issues of this novel communication system and elaborate on some research directions for calcium signaling.

Published in:

Wireless Communications, IEEE  (Volume:19 ,  Issue: 5 )

Date of Publication:

Oct. 2012

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