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This special issue of the IEEE Journal of Solid-State Circuits is dedicated to the papers taken from the best of the Data Converters, RF, Analog,Wireless Communications, andWireline Communications sessions at the IEEE International Solid-State Circuits Conference (ISSCC) in San Francisco, CA, USA in February 2012. The guest editors of this special issue would like to thank all the presenters at the conference from these sessions for making the selection process quite difficult, as the overall standard was quite high. We would also like to extend our appreciation to the selected authors for their timely and excellent submissions, and to those reviewers who helped ensure the papers met our high quality level. Seven papers have been selected from the data converter sessions in the 2012 ISSCC for inclusion in this special issue. Seven papers have been selected from the three RF sessions at the ISSCC 2012, ranging from radio receivers to power amplifiers, PLL andmodulators, and THz imagers and power sources. The six papers in the Analog Techniques Section tackle highpower to high-speed applications that span technology nodes from 0.8μm down to 65 nm, utilizing BCD, BiCMOS, and CMOS processes in various designs. Six papers have been carefully selected from three Wireless sessions at ISSCC 2012. These papers cover a wide range of topics which represent diversified applications in wireless communications. Finally, five papers have been selected from three Wireline sessions at ISSCC 2012.