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Physical parts of a system to interacting software components. In many cyber-physical systems considered nowadays, the system's parts form a network structure with concurrent entities and the need of seamless scaling and fault-tolerant information dissemination and decentralized methods. In this contribution we point out that swarm intelligence approaches may be well suited for CPS with networked components. As an example, we present our self-adaptive and distributed vehicle route guidance approach, termed BeeJamA, which provides drivers safely with routing directions well before each intersection. Our approach is based on a multi-agent system which is inspired by the honey bee behavior and relies on a decentralized vehicle-to-infrastructure architecture.