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To solve the dynamic and complex problem of production scheduling, depending on the introduction between multi-agent and hybrid genetic algorithm in hybrid system production scheduling, this paper proposed a hybrid system production scheduling method based on multi-agent. In this method, the logic framework and cooperation mechanism of hybrid system dynamic production scheduling and were established. Finally, a simulation system of hybrid system dynamic production scheduling based on multi-agent was demonstrated and validated by QUEST software. It has shown the proposed method can improve the benefit of production scheduling, and provide a support for adapting to complex and dynamic production scheduling in hybrid system production.