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Design and Implementation of a Wireless Capsule Suitable for Autofluorescence Intensity Detection in Biological Tissues

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5 Author(s)
Al-Rawhani, M.A. ; Sch. of Eng., Univ. of Glasgow, Glasgow, UK ; Chitnis, D. ; Beeley, J. ; Collins, S.
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We report on the design, fabrication, testing, and packaging of a miniaturized system capable of detecting autofluorescence (AF) from mammalian intestinal tissue. The system comprises an application-specific integrated circuit (ASIC), light-emitting diode, optical filters, control unit, and radio transmitter. The ASIC contains a high-voltage charge pump and single-photon avalanche diode detector (SPAD). The charge pump biases the SPAD above its breakdown voltage to operate in Geiger mode. The SPAD offers a photon detection efficiency of 37% at 520 nm, which corresponds to the AF emission peak of the principle human intestinal fluorophore, flavin adenine dinucleotide. The ASIC was fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3 V and draws an average of 7.1 mA, enabling up to 23 h of continuous operation from two 165-mAh SR44 batteries.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:60 ,  Issue: 1 )

Date of Publication:

Jan. 2013

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