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Mobile and multimedia applications are more and more used in the current Internet. For these applications, a set of Transport protocols are proposed aimed at aiding the end-to-end communication. However, to face the challenge of providing a sufficient Quality of Service (QoS) to the final users, a new generation of Transport protocols that takes into account dynamically and autonomously the evolvement of both applications QoS requirements and network context changes is needed. The goal of this paper is to provide contributions aimed at illustrating how the autonomic computing paradigm may be applied to a multi-path Transport protocol called Multipath TCP (MPTCP) in order to provide as much as possible QoS for mobile and multimedia applications. Several QoS-aware mechanisms are proposed and evaluated as well as an ontology-based semantic model for the dynamic discovery of MPTCP mechanisms is also presented.