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We report on a 2D simulation study of a couple of mid-infrared quantum cascade lasers based on the integration of a number of optoelectronic models. Quantum mechanical computation was performed to find the quantization states and a rate equation approach was used to compute the optical gain. Temperature and field dependence effects are taken into account in optical gain model to make a realistic simulation of QCLs. The simulation study compared the integrated models with experimental data with different structures and at different temperatures. Reasonable agreements between experiment and simulation have been obtained.