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Formation and cell translocation of carbon nanotube-fibrinogen protein corona

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7 Author(s)
Chen, Ran ; Nano-Biophysics and Soft Matter Laboratory, COMSET, Clemson University, Clemson, South Carolina 29634, USA ; Radic, Slaven ; Choudhary, Poonam ; Ledwell, Kimberley G.
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The binding of plasma fibrinogen with both single-walled and multi-walled carbon nanotubes (SWNTs and MWNTs) has been examined. Specifically, our absorbance study indicated that MWNTs were coated with multi-layers of fibrinogen to render a “hard protein corona,” while SWNTs were adsorbed with thin layers of the protein to precipitate out of the aqueous phase. In addition, static quenching as a result of energy transfer from fluorescently labeled fibrinogen to their nanotube substrates was revealed by Stern-Volmer analysis. When exposed to HT-29 cells, the nanotubes and fibrinogen could readily dissociate, possibly stemming from their differential affinities for the amphiphilic membrane bilayer.

Published in:

Applied Physics Letters  (Volume:101 ,  Issue: 13 )

Date of Publication:

Sep 2012

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