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This special issue is devoted to the new research addressing challenges in the areas of wireless computing and networking. Wireless computing and networking has enabled heterogeneous access technologies for providing services to ubiquitous users. The demanding networking environment of wireless communications imposes many challenges, such as channel estimation, network protocol design, resource management, and systematic design. Due to nonuniform spectrum allocation, various radio resource management policies, economic concerns, scarcity of radio resources, and user mobility, overcoming these issues becomes more demanding.