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Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

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7 Author(s)
Tu, Juan ; Key Laboratory of Modern Acoustics (Nanjing University), Ministry of Education, Nanjing, Jiangsu 210093, China ; Ha Hwang, Joo ; Chen, Tao ; Fan, Tingbo
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High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivo thermocouple measurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated for temperature at distal vessel wall exceeding 44 °C, although different tissue depths and inclusions could affect the DC threshold. The results demonstrate clinic potentials of achieving controllable hyperthermia by adjusting pHIFU DCs, while minimizing perivascular thermal injury.

Published in:

Applied Physics Letters  (Volume:101 ,  Issue: 12 )

Date of Publication:

Sep 2012

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